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* Date : 05-14-2011 - 05:20 AM (4952 days ago),
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"Positron emission tomography in the management of papillary thyroid carcinoma in children: is there a role?"
Fluorodeoxyglucose-Positron Emission Tomography (FDG-PET) is being more frequently used in the evaluation of patients with papillary thyroid carcinoma (PTC) who have serologic evidence of disease and a negative. radioiodine (RAI) scan. Imaging with FDG-PET may localize disease, and there is accruing evidence that, in adults, increased FDG uptake by metastatic lesions is associated with a poorer prognosis. The utility of FDG-PET in children with PTC has not been studied. In this limited retrospective study, FDG-PET does not appear to be a highly sensitive test for localizing tumor in children with PTC and evidence of persistent disease. This may be explained by the frequently indolent nature of pediatric PTC or by the fact that metastatic lesions < 1cm in size, as is often the case, are below the limits of resolution for FDG uptake. Similar to adults, FDG-PET may play a role in determining prognosis or the degree of intervention necessary. Further studies are needed to define further the role of FDGPET in the management of childhood PTC.
Journal/Publication - Hormone Research, Sep 2008
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