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* Date : 06-08-2009 - 07:33 PM (5434 days ago),
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Acute Vertebral Compression Fractures in Patients with Multiple Myeloma: Evaluation of Vertebral Body Edema Patterns on MR Imaging and the Implications for Vertebroplasty.
The edema in a fractured vertebra is likely related to an inflammatory healing response with increased fluid in the bone. As a compression fracture heals, the edema typically resolves along with the patient’s pain. Previous reports have documented the utility of percutaneous vertebroplasty in chronic compression fractures without associated edema on MR imaging.6, 7 It is important to accurately identify compression fractures that might be amenable to vertebroplasty treatment, given the efficacy of this procedure. Acute or subacute compression fractures in osteoporosis and multiple myeloma generally mount a reparative response with associated edema; however, the edema present in patients with multiple myeloma may be decreased or even absent as demonstrated in the previously mentioned patients (Figs 1B and 2A, -B). Therefore, practitioners who perform percutaneous vertebroplasty procedures should consider this fact when evaluating patients with multiple myeloma and deciding whether to treat a fractured level. In our vertebroplasty experience, in treating patients with multiple myeloma, the edema present in acute or subacute compression fractures is subjectively decreased or absent compared with benign osteoporotic fractures. Because this article includes only 2 patients, further evaluation with a larger series is required to fully define the differences in edema response encountered in patients with multiple myeloma. In these patients with severe back pain, clinical findings along with manual palpation may be more important than edema on MR imaging in determining the potential response to vertebroplasty.
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