Clinical factors, but not C-reactive protein, predict progression of calcific aortic valve disease: the Cardiovascular Health Study

		SuggestADoctor.com > Gian Mendez NOVARO MD
Clinical factors, but not C-reactive protein, predict progression of calcific aortic valve disease: the Cardiovascular Health Study

Clinical factors, but not C-reactive protein, predict progression of calcific aortic valve disease: the Cardiovascular Health Study

Gian Mendez NOVARO MD

Florida, Weston
Cardiology

Has special expertise in certain sickness

Email This Doctor

Article Details

* Date : 03-24-2009 - 10:09 PM (5511 days ago),

* Characters : 1842, Words : 278, Size : 1.80 Kb.

Clinical factors, but not C-reactive protein, predict progression of calcific aortic valve disease: the Cardiovascular Health Study

OBJECTIVES: The purpose of this study was to examine the relationship between C-reactive protein (CRP) and calcific aortic valve disease in a large, randomly selected, population-based cohort. BACKGROUND: The pathobiology of calcific aortic stenosis involves an active inflammatory, atheromatous, osteogenic process. Elevations in CRP, a measure of systemic inflammation, have been associated with aortic stenosis. METHODS: Two-dimensional and Doppler echocardiography and CRP measurement were performed at baseline in 5,621 participants in the Cardiovascular Health Study. Multivariable analysis was used to identify CRP as a predictor of baseline and incident aortic stenosis. RESULTS: At a mean echocardiographic follow-up of 5 years, 9% of subjects with aortic sclerosis progressed to some degree of aortic stenosis. Increasing age (odds ratio [OR] 1.13, 95% confidence interval [CI] 1.09 to 1.16; p < 0.001) and male gender (OR 3.05, 95% CI 1.76 to 5.27; p < 0.001) were related to risk of incident aortic stenosis, whereas increasing height (OR 0.96, 95% CI 0.94 to 0.99; p = 0.013) and African-American ethnicity conveyed a lower risk (OR 0.49, 95% CI 0.25 to 0.95; p = 0.035). C-reactive protein, treated as a continuous variable, was not associated with baseline aortic stenosis, progression to aortic sclerosis (adjusted OR 0.93, 95% CI 0.85 to 1.02; p = 0.107), or progression to aortic stenosis (adjusted OR 0.85, 95% CI 0.70 to 1.03; p = 0.092). CONCLUSIONS: In this large population-based cohort, approximately 9% of subjects with aortic sclerosis progressed to aortic stenosis over a 5-year follow-up period. There was no association between CRP levels and the presence of calcific aortic-valve disease or incident aortic stenosis. C-reactive protein appears to be a poor predictor of subclinical calcific aortic-valve disease.

Return to Doctor's Page
Email This Doctor

To Quote this article, you should add: :

All rights of Article "Clinical factors, but not C-reactive protein, predict progression of calcific aortic valve disease: the Cardiovascular Health Study" belongs to Gian Mendez NOVARO MD and it is published at SuggestADoctor.com (http://www.suggestadoctor.com) Health Articles Library.

With this notice, you can quote reasonable amount of text from this article but you have to get permission from its author to republish or redistribute it fully.

Other Articles by Gian Mendez NOVARO MD:

In-Hospital İnitiation Of Lipid-Lowering Therapy After Coronary İntervention As A Predictor Of Long-Term Utilization: A Propensity Analysis

Reclassification Of Patients For Aggressive Cholesterol Treatment: Additive Value Of Multi-Slice Coronary Angiography To The National Cholesterol Education Program Guidelines

Some other Health Articles from our Library:

Facial Plastic Surgery Earns İts Place On ‘most Popular’ Holiday Gift List , Rich CASTELLANO MD

Brotox A Phenomenon Popular İn Tampa Bay , Rich CASTELLANO MD

Proof Positive, Facial Lifting Procedures Work , Rich CASTELLANO MD

Liposuction Is A Treatment For Obesity , Thomas LOCKE MD

Weight Loss After Pregnancy , Michele CAVENEE MD

Lymphedema — An Overview , Margarita CORREA MD

Identification Of A Novel Compound Heterozygous Mutation Of The 5 Alpha-Reductase Type 2 (Srd5a2) Gene İn An Extreme Premature 46, Xy Male İnfant , Cayce JEHAIMI MD

"Positron Emission Tomography İn The Management Of Papillary Thyroid Carcinoma İn Children: İs There A Role?" , Cayce JEHAIMI MD

"Primary Pigmented Nodular Adrenocortical Disease İn A Patient With Carney Complex: A Case Report" , Cayce JEHAIMI MD

"Novel Intervening Sequence Mutation At The 5 , Cayce JEHAIMI MD

"Polycystic Ovaries And Adrenal Insufficiency İn A Young Pubescent Female With Lipoid Congenital Adrenal Hyperplasia Due To Splice Mutation Of The Star Gene: A Case Report & Review Of The Literature" , Cayce JEHAIMI MD

"Sexual Precocity İn A 2-Year-Old Boy Caused By Indirect Exposure To Testosterone Cream" , Cayce JEHAIMI MD

Chemical Addictions , Minh Anh HAN MD

Muscle Knot? It Might Be A Trigger Point , Minh Anh HAN MD

Cancer Rehabilitation Experience Over Twelve Years. Abstract- Amsterdam, Netherlands 2009 , Susan E CARTER MD

Cancer And Exercise. Abstract Brisbane, Australia 2009 , Susan E CARTER MD

Is Bacteria Causing You To Feel Bloated Or Have Excessive Flatulence? , Rakesh GUPTA MD

Stress And Irritable Bowel Syndrome İn The Real World , Rakesh GUPTA MD

Roger Rabbit Medical Mishaps , Mark SARACINO MD

Dangerous Herb And Drug Combinations , Mark SARACINO MD

All articles published in SuggestADoctor.com is written by Medical Doctors who are also our site members. So although they are considered as depandable resources they should never be used by site visitors without consulting with their own medical doctors, nor should be taken for granted about their being updated or accurate.These articles are for information purposes only and every information they contain must be checked with your own Medical professional.