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Cancer and Exercise. Abstract Brisbane, australia 2009

Colorado, Greeley
Obstetrics & Gynecology
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* Date : 04-26-2011 - 02:40 AM (4542 days ago),

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Cancer and Exercise. Abstract Brisbane, australia 2009

Cancer Rehabilitation: Cancer and Exercise

Susan D. Carter1,2, Chris P. Repka1, Lisa K. Sprod1, Reid Hayward1, Carole M. Schneider1. 1Rocky Mountain Cancer Rehabilitation Institute, University of Northern Colorado, Greeley, CO. 2Regional Breast Center of Northern Colorado, Greeley, CO.

New cancer treatments have led to reductions in cancer mortality. However, patients experience treatment related negative physiological and psychological side-effects. PURPOSE: To investigate the physiological and psychological benefits of a prescriptive exercise intervention in cancer survivors. METHODS: One hundred and thirty-five cancer survivors received cancer and medical history screening as well as assessments of cardiovascular and muscular endurance, flexibility, fatigue, depression, and quality of life. Following the exercise assessments, cancer survivors, during treatment (DTm group) or following treatment (FTm group), trained aerobically for 6 months utilizing an individualized exercise intervention. RESULTS: Cardiopulmonary function (systolic blood pressure, time on treadmill) improved in the DTm group (P <.05), whereas the FTm group showed improvements (P <.05) in systolic and diastolic blood pressure, resting heart rate, predicted VO2max, and time on treadmill. The DTm group showed significant improvements in upper-body (+79.1%) and lower-body (+49.7%) muscular endurance while maintaining core endurance and flexibility. The FTm group showed improvements in upper-body (+46.8%), lower-body (+67.1%) and core (+32.5%) muscular endurance and flexibility (+6.2%). Psychologically, the DTm group showed improvements in fatigue (-32.1%), depression (–43.0%) and quality of life (+11.5%). Likewise, the FTm group showed improvements in fatigue (-32.6%), depression (–25.6%) and quality of life (+7.2%). CONCLUSIONS: Moderate-intensity individualized prescriptive exercise is an effective means to augment cardiovascular and muscular function and improve the quality of life of cancer survivors. Our animal studies suggest that the mechanisms may include adaptations in antioxidant defenses, expression of heat shock proteins, and regulation of apoptosis.

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